Open Access
Article
Clinical biomarkers in esophageal adenocarcinoma
Antonio Biondi1,Marcello Migliore1,Giuseppe Strano1,Salvatore Vadala1,Alessandro Tropea1,Francesco Basile1
1
Section of General Surgery and Oncology, Department of General Surgery, University Medical School of Catania, Catania, Italy. biondian@tin.it
DOI: 10.2741/E107 Volume 2 Issue 2, pp.489-494
Published: 01 January 2010
(This article belongs to the Special Issue Biochemical markers in biological fluids)
Abstract

This review describes genetic and molecular changes related to adenocarcinoma of the esophagus and gastroesophageal junction (GEJ) with emphasis on prognostic value and possibilities for targeted therapy in clinical setting. The progression of Barrett's esophagus to adenocarcinoma has been the focus of particular scrutiny, and a number of potential tissue and serum-based disease biomarkers have emerged. Tissue biomarkers allowing risk stratification of Barrett's are reviewed as well as strategies currently being used to discover novel biomarkers that will facilitate the early detection of esophageal adenocarcinoma.

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Antonio Biondi, Marcello Migliore, Giuseppe Strano, Salvatore Vadala, Alessandro Tropea, Francesco Basile. Clinical biomarkers in esophageal adenocarcinoma. Frontiers in Bioscience-Elite. 2010. 2(2); 489-494.