Open Access
Involvement of PARPs in cell death
Francesca Aredia1,*,Anna Ivana Scovassi1
Istituto di Genetica Molecolare CNR, Pavia, Italy
DOI: 10.2741/707 Volume 6 Issue 2, pp.308-317
Published: 01 June 2014
(This article belongs to the Special Issue Involvement of PARPs in cell death)
*Corresponding Author(s):  
Francesca Aredia

Poly(ADP-ribosylation), an NAD dependent reaction culminating in the formation of ADP-ribose monomers, and their following polymerization, is activated as an emergency process in crucial situations such as DNA damage and cellular stress; due to this crucial function, the modulation of poly(ADP-ribosylation) during cell death has been investigated. This review will describe the properties of poly(ADP-ribose) as a signalling molecule in different paradigms of cell death, i.e. apoptosis, parthanatos, necroptosis and autophagy.

Key words

Apoptosis, Autophagy, Necroptosis, PARP, PAR, Parthanatos, Review

Share and Cite
Francesca Aredia, Anna Ivana Scovassi. Involvement of PARPs in cell death. Frontiers in Bioscience-Elite. 2014. 6(2); 308-317.