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Review
Involvement of PARPs in cell death
Francesca Aredia1,*,Anna Ivana Scovassi1
1
Istituto di Genetica Molecolare CNR, Pavia, Italy
DOI: 10.2741/707 Volume 6 Issue 2, pp.308-317
Published: 01 June 2014
(This article belongs to the Special Issue Involvement of PARPs in cell death)
*Corresponding Author(s):  
Francesca Aredia
E-mail:  
Abstract

Poly(ADP-ribosylation), an NAD dependent reaction culminating in the formation of ADP-ribose monomers, and their following polymerization, is activated as an emergency process in crucial situations such as DNA damage and cellular stress; due to this crucial function, the modulation of poly(ADP-ribosylation) during cell death has been investigated. This review will describe the properties of poly(ADP-ribose) as a signalling molecule in different paradigms of cell death, i.e. apoptosis, parthanatos, necroptosis and autophagy.


Key words

Apoptosis, Autophagy, Necroptosis, PARP, PAR, Parthanatos, Review

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Francesca Aredia, Anna Ivana Scovassi. Involvement of PARPs in cell death. Frontiers in Bioscience-Elite. 2014. 6(2); 308-317.