Open Access

Estrogen receptors in lipid raft signalling complexes for neuroprotection

Raquel Marin1,2,3,*,Jorge Marrero-Alonso3,4,Cecilia Fernandez1,3,Debora Cury1,3,5,Mario Diaz2,3,4
Laboratory of Cellular Neurobiology, Department of Physiology, School of Medicine, La Laguna University, Tenerife, Spain
Institute of Biomedical Technologies, La Laguna University, Tenerife, Spain
Canarian Institute of Cancer Research, Tenerife, Spain,
Department of Animal Biology, Faculty of Biology, La Laguna University, Tenerife, Spain
Department of Anatomy, Pathological Anatomy and Histology, School of Medicine, La Laguna University, Tenerife, Spain
DOI: 10.2741/471 Volume 4 Issue 4, pp.1420-1433
Published: 01 January 2012
(This article belongs to the Special Issue Estrogen receptors in lipid raft signalling)
*Corresponding Author(s):  
Raquel Marin

Estrogens exert a plethora of actions conducted to brain preservation and functioning. Some of these actions are initiated in lipid rafts, which are particular microstructures of the plasma membrane. Preservation of lipid raft structure in neurons is essential for signal transduction against different injuries, such as Alzheimer’s disease (AD). These membrane structures appear to be disrupted as this neuropathology evolves, and that may largely contribute to dysfunction of raft resident proteins involved in intracellular signalling. This review includes a survey of some protein interactions that are involved in the structural maintenance and signal transduction mechanisms for neuronal survival against AD. Particularly relevant are the rapid mechanisms developed by estrogen to prevent neuronal death, through membrane estrogen receptors (mER) interactions with a voltage-dependent anion channel (VDAC) and other protein markers within neuronal lipid rafts. These interactions may have important consequences in estrogen mechanisms to achieve neuroprotection against amyloid beta (Abeta-induced toxicity).

Key words

Membrane estrogen receptor, Lipid rafts, Neuroprotection, Voltage-dependent anion channel, Signalling platforms in neurons; Alzheimer’s disease, Review

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Raquel Marin, Jorge Marrero-Alonso, Cecilia Fernandez, Debora Cury, Mario Diaz. Estrogen receptors in lipid raft signalling complexes for neuroprotection. Frontiers in Bioscience-Elite. 2012. 4(4); 1420-1433.