Open Access
Review

Proteinase-activated receptors in the endometrium and endometriosis

Yutaka Osuga1,*,Yasushi Hirota1,Osamu Yoshino1,Tetsuya Hirata1,Kaori Koga1,Yuji Taketani1
1
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan
DOI: 10.2741/416 Volume 4 Issue 2, pp.755-767
Published: 01 January 2012
(This article belongs to the Special Issue Frontiers in endometriosis)
*Corresponding Author(s):  
Yutaka Osuga
E-mail:  
yutakaos-tky@umin.ac.jp
Abstract

Proteinase-activated receptors (PARs) are G protein-coupled receptors activated by various proteinases. PARs play important roles in haemostasis, thrombosis, and inflammation. PAR1 and PAR2 are expressed in endometrial cells from the eutopic endometrium and endometriotic cells derived from endometriotic lesions. A typical activator of PAR1, thrombin, and a typical activator of PAR2, tryptase, are produced in the endometrium as well as endometriotic lesions. PAR1 activation in endometrial stromal cells induces production of vascular endothelial growth factor and matrix metalloproteinases, and increases activities of tissue-type and urokinase-type plasminogen activator. PAR2 activation in endometrial stromal cells stimulates interleukin (IL)-8 and stem cell factor production and proliferation of the cells. PAR1 activation in endometriotic stromal cells induces production of IL-8, monocyte chemotactic protein-1, and cyclooxygenase-2, and proliferation of the cells. PAR2 activation in endometriotic stromal cells increases secretion of IL-6 and IL-8, and the number of the cells. These findings indicate a wide range of function of PAR1 and PAR2 in the endometrium and endometriosis, and suggest PAR1 and PAR2 as possible therapeutic targets for endometriosis.

Key words

Endometrium, Endometriosis, ProteinaseActivated Receptor, Review

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Yutaka Osuga, Yasushi Hirota, Osamu Yoshino, Tetsuya Hirata, Kaori Koga, Yuji Taketani. Proteinase-activated receptors in the endometrium and endometriosis. Frontiers in Bioscience-Elite. 2012. 4(2); 755-767.