Open Access

Peripheral cholesterol, metabolic disorders and Alzheimer’s disease

Maria Dolores Ledesma1,*,Carlos Gerardo Dotti1,2,3
Center for Molecular Biology Severo Ochoa CSIC-UAM, Madrid, Spain
VIB Department of Molecular and Developmental Geneticsm, Belgium
Catholic University of Leuven, Department of Human Genetics, Leuven, Belgium
DOI: 10.2741/368 Volume 4 Issue 1, pp.181-194
Published: 01 January 2012
(This article belongs to the Special Issue Alzheimer's disease)
*Corresponding Author(s):  
Maria Dolores Ledesma

Strong correlations have been made between high levels of blood cholesterol and the risk to suffer Alzheimer’s disease (AD). The question arises on how a peripheral event contributes to a disease that so severely affects the integrity and function of the Central Nervous System. Hypercholesterolemia has been also associated to peripheral metabolic disorders like diabetes, obesity or atherosclerosis that, in turn, predispose to AD. Here we review data, which point to alterations in blood cholesterol levels as a link between these metabolic disorders and AD. We describe and discuss common, cholesterol-related, molecular mechanisms and strategies to fight these conditions that, altogether, constitute a major cause of death in our societies.

Key words

Hypercholesterolemia, Diabetes, Obesity, Atherosclerosis, Alzheimer’s Disease, Insulin, Leptin, Brain Blood Barrier, Review

Share and Cite
Maria Dolores Ledesma, Carlos Gerardo Dotti. Peripheral cholesterol, metabolic disorders and Alzheimer’s disease. Frontiers in Bioscience-Elite. 2012. 4(1); 181-194.